3,5-Dichloro-2,4,6-trifluorobenzonitrile synthesis
- Product Name:3,5-Dichloro-2,4,6-trifluorobenzonitrile
- CAS Number:31881-89-7
- Molecular formula:C7Cl2F3N
- Molecular Weight:225.98
20925-85-3
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Yield:31881-89-7 98.6%
Reaction Conditions:
with potassium fluoride in sulfolane at 130 - 140; for 3 h;Inert atmosphere;Time;
Steps:
1 Example 1
pentachlorobenzonitrile (20g, 72.6mmol),Anhydrous potassium fluoride (13.9 g, 239.2 mmol) was added to sulfolane (100 mL).Under nitrogen protection,Heat to 130-140°C,Insulation reaction 3h.The reaction is over,The reaction solution was cooled to room temperature.Add methyl tert-butyl ether 100mL and 200mL water,Extraction layering.Separate the organic phase,Wash with 100mL water,Dry with anhydrous sodium sulfate,filter,Desolventizing reduced pressure to give 3,5-Dichloro-2,4,6-trifluorobenzonitrile(16.2 g of, yield 98.6%),HPLC content 98.9%.
References:
CN107778183,2018,A Location in patent:Paragraph 0043; 0045; 0046; 0048; 0050
