ChemicalBook CAS DataBase List 3,5-Dibromobenzaldehyde

3,5-Dibromobenzaldehyde synthesis

9synthesis methods

Product Name:3,5-Dibromobenzaldehyde
CAS Number:56990-02-4
Molecular formula:C7H4Br2O
Molecular Weight:263.91

3,5-Dibromobenzaldehyde is a dibrominated benzaldehyde that is a very useful building block for the preparation of a wide range of biologically active compounds such as a antibacterials. The synthesis process is that 1,3,5-tribromobenzene in N,N-dimethylformamide solution, reacts with Grignard solution and purifies to obtain 3,5-Dibromobenzaldehyde as white solid, yield, 45%.

56908-88-4 Synthesis

56908-88-4
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$6.00/1g

56990-02-4
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$6.00/1g

Yield:56990-02-4 92%

Reaction Conditions:

with 4-methylmorpholine N-oxide in tetrahydrofuran for 12 h;Reflux;

Steps:

1.d synthesis of Intermediate D
A solution of compound C (3.29 g, 10 mmol) and 4-methyl-n-oxo morpholine (3.51 g, 30 mmol) were dissolved in 60 mL of tetrahydrofuran and the reaction mixture was heated under reflux for 12 hours. The organic compound was dried over magnesium sulfate and dried over silica gel column chromatography using dichloromethane / petroleum ether (v / v = 2: 3) as eluent. After drying and steaming, the mixture was dried to give the intermediate D (2.42 g, yield 92%) as a white solid.

References:

Dalian University of Technology;Cui Yuting;Liu Jianhui;Min Xiangting CN106946777, 2017, A Location in patent:Paragraph 0063-0065

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626-39-1 Synthesis