ChemicalBook CAS DataBase List 3,5'-Di-O-acetyl-2'-deoxyuridine

3,5'-Di-O-acetyl-2'-deoxyuridine synthesis

8synthesis methods

Product Name:3,5'-Di-O-acetyl-2'-deoxyuridine
CAS Number:13030-62-1
Molecular formula:C13H16N2O7
Molecular Weight:312.28

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Yield:13030-62-1 96%

Reaction Conditions:

with O-(3-sulfopropyl)-functionalized nano γ-Al₂O₃ in neat (no solvent) at 20 - 50; for 0.5 h;

Steps:

1.4 Typical procedure for the preparation of 2c

General procedure: To a stirred suspension of d-glucose (1 mmol) in acetic anhydride (5.1 mmol) at room temperature was added sulfonic acid functionalized nano γ-Al₂O₃ (50 mg). The mixture was stirred at 50 °C for 40 min. After completion of the reaction (TLC), the mixture was put into diethyl ether (50 mL) and microporous filtration (microporous membrane: PVDF, pore sizes: 0.1 μm). The solvents were removed under reduced pressure and the crude product was passed through a short pad of silica to give pure acetylated product 2c. The catalyst was washed with absolute EtOH, dried and re-used for a consecutive run under the same reaction conditions.

References:

Wu, Liqiang;Yin, Zhikui [Carbohydrate Research,2013,vol. 365,p. 14 - 19]

951-78-0 Synthesis