3-(4-iodophenyl)acrylic acid synthesis

4synthesis methods

Product Name:3-(4-iodophenyl)acrylic acid
CAS Number:113641-76-2
Molecular formula:C9H7IO2
Molecular Weight:274.06

2-Propenoic acid, 3-(4-iodophenyl)-, ethyl ester

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113641-76-2
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Yield:113641-76-2 91%

Reaction Conditions:

with lithium hydroxide;water in tetrahydrofuran;methanol at 20; for 48 h;

Steps:

A solution of ethyl-4-iodo-cimiamate (3.2g, 10. 5mmol) in methanol (25mL), tetrahydrofuran (25mL) and water (15mL) was treated with lithium hydroxide monohydrate (4.2g, 100mmol) and the resulting reaction mixture was stirred at ambient temperature over 2 days. The volatiles were evaporated in vacuo and the residue was neutralized with saturated aqueous ammonium chloride solution. The precipitated solid was filtered, washed with water and hexane and dried to afford the title product as a white solid (2.9g, 91%) It was used as such for the next step.

References:

WO2005/58301,2005,A1 Location in patent:Page/Page column 76-77

141-82-2 Synthesis