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13389-73-6

3,4'-DIMETHYLBENZHYDROL synthesis

2synthesis methods
-

Yield:13389-73-6 95%

Reaction Conditions:

Stage #1: 3-Iodotoluenewith TurboGrignard in tetrahydrofuran at 20;
Stage #2: 4-methyl-benzaldehyde in tetrahydrofuran at 20; under 7757.43 Torr;
Stage #3: with ammonium chloride in tetrahydrofuran;water;

References:

Brodmann, Tobias;Koos, Peter;Metzger, Albrecht;Knochel, Paul;Ley, Steven V. [Organic Process Research and Development,2012,vol. 16,# 5,p. 1102 - 1113] Location in patent:experimental part