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ChemicalBook CAS DataBase List 3,4-Diethoxybenzyl alcohol
83459-29-4

3,4-Diethoxybenzyl alcohol synthesis

4synthesis methods
-

Yield:83459-29-4 97%

Reaction Conditions:

with hydrogen in methanol at 20; for 4 h;chemoselective reaction;

Steps:

Typical procedure for hydrogenation of 3,4,5-trimethoxybenzyl-aldehyde (1a) to3,4,5-trimethoxybenzyl alcohol

General procedure: A mixture of 1a (196 mg, 1 mmol) and 1%Pd/Ni bimetallic catalyst9 (60 mg, 30 wt %) in MeOH (10 mL) was stirred underH2 at room temperature and atmospheric pressure (on an atmosphericpressure hydrogenation apparatus) until the absorption of hydrogen ceased(3.5 h). After the catalyst was removed off by a magnetic stirring bar, thesolution was evaporated in a vaporator to give the product 2a

References:

Liu, Chulong;Bao, Hailin;Wang, Dingsheng;Wang, Xinyan;Li, Yadong;Hu, Yuefei [Tetrahedron Letters,2015,vol. 56,# 46,p. 6460 - 6462]

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