ChemicalBook CAS DataBase List 3,4-DICHLOROPHENYLACETYLENE

3,4-DICHLOROPHENYLACETYLENE synthesis

5synthesis methods

Product Name:3,4-DICHLOROPHENYLACETYLENE
CAS Number:556112-20-0
Molecular formula:C8H4Cl2
Molecular Weight:171.02

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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556112-20-0
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Yield: 94%

Reaction Conditions:

with methanol;potassium hydroxide in dichloromethane at 20; for 1 h;

Steps:

1
Synthesis of Compound 440. A mixture of 439 (2.54 g, 10.4 mmol) and potassium hydroxide (1.17 g, 20.9 mmol) in methanol (20 mL) and methylene chloride (10 mL) was stirred at room temperature for 1 h. After this time, the reaction mixture was poured into water (30 mL) and extracted with methylene chloride (3 x 30 mL). The combined organic extracts were dried over magnesium sulfate, filtered and concentrated to afford 440 (1.68 g, 94%) which was used as an appropriate alkyne in Example 9 without further purification.

References:

RESOLVYX PHARMACEUTICALS, INC.;GJORSTRUP, Per WO2010/91226, 2010, A1 Location in patent:Page/Page column 123-124

13965-03-2 Synthesis