ChemicalBook CAS DataBase List 3-(4-BROMO-PHENYL)-PROPAN-1-OL

3-(4-BROMO-PHENYL)-PROPAN-1-OL synthesis

11synthesis methods

Product Name:3-(4-BROMO-PHENYL)-PROPAN-1-OL
CAS Number:25574-11-2
Molecular formula:C9H11BrO
Molecular Weight:215.09

75567-84-9 Synthesis

75567-84-9
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91763-35-8
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Yield:91763-35-8 319 g

Reaction Conditions:

with aluminum (III) chloride;sodium tetrahydroborate in 1,2-dimethoxyethane at 20 - 50; for 4 h;Large scale;

Steps:

1.2

The second step:Add M1 300g, ethylene glycol dimethyl ether 2000g, sodium borohydride 70g, and stir in a 5L reaction flask.Add 82g of aluminum trichloride in batches at room temperature, add 2 hours, the system will automatically heat up, and finally keep warm at 50 °C for 2 hours.Sampling plate analysis, the reaction is over, and the reaction is stopped.Pour into ice water for hydrolysis, adjust to pH=2 with sulfuric acid, extract with ethyl acetate, wash with 10% sodium bicarbonate until neutral, separate the liquid, and steam the solvent.Obtained intermediate M2(319 g, molar yield 90%, HPLC purity 98.6%).

References:

CN108409585,2018,A Location in patent:Paragraph 0050; 0052