ChemicalBook CAS DataBase List 3,4,5-Trifluoroaniline

3,4,5-Trifluoroaniline synthesis

5synthesis methods

Product Name:3,4,5-Trifluoroaniline
CAS Number:163733-96-8
Molecular formula:C6H4F3N
Molecular Weight:147.1

138526-69-9 Synthesis

138526-69-9
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$6.00/5g

163733-96-8
224 suppliers
$6.00/1g

Yield:163733-96-8 95.1%

Reaction Conditions:

with ammonium hydroxide at 160; under 11251.1 Torr; for 10 h;Autoclave;Temperature;Pressure;

Steps:

1; 2; 3; 4
(1) 160 g of 3,4,5-trifluorobromobenzene was added to a 1000 mL autoclave.6.4g of Cu2O-bipyridine catalyst,Measure 480mL of ammonia water (ammonia concentration is 25%),Add to the autoclave, seal the autoclave, and raise the temperature to 160 ° C with stirring.The stirring speed is 500r/min, the reaction is 10h, and the pressure during the reaction reaches up to about 1.5Mpa;When the temperature is lowered to room temperature, the autoclave is opened, the material in the kettle is transferred out for steam distillation, and the distilled material is cooled to obtain a white solid, which is filtered and dried.Obtaining a white product of about 106.4 g, a purity of 99.6%, and a molar yield of 95.1%;

References:

Zhejiang Linjiang Chemical Co., Ltd.;Yin Xin;Wu Wenliang;Yang Jiangyu;Yan Zehua;Wang Qijun CN109456150, 2019, A Location in patent:Paragraph 0038-0039; 0043-0044; 0048-0049; 0053-0054

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