3-[(2-Chlorophenyl)amino]propanenitrile synthesis
- Product Name:3-[(2-Chlorophenyl)amino]propanenitrile
- CAS Number:94-89-3
- Molecular formula:C9H9ClN2
- Molecular Weight:180.63
![3-[(4-CHLOROPHENYL)AMINO]PROPANENITRILE](/CAS/GIF/41833-57-2.gif)
Yield:-
Reaction Conditions:
with indium(III) triflate;trichloroisocyanuric acid in toluene at 90; for 12 h;Overall yield = 7 percent;
Steps:
8 Example 8: Preparation of 2-chloro 3-anilinopropionitrile (8) from 3-anilinopropionitrile.
In an air atmosphere, indium trifluoromethanesulfonate (5mol%, 5.6mg), 3-anilinopropionitrile (0.2mmol, 29.2mg), trichloroisocyanuric acid (0.07mmol, 16.3mg) and a magnetic stir bar Add to 35mL glass pressure tube. Toluene (4 mL) was then added, and the reaction tube was reacted at 90°C for 12 hours. After the reaction is complete, cool the reaction system to room temperature, open the reaction vessel at room temperature, add 10 mL of water; extract with 30 mL of dichloromethane, collect the organic phase, dry the organic phase with anhydrous sodium sulfate, and purify the organic layer by column chromatography. The yield of the pure product is 75%, and the gas phase selectivity of the ortho and para position is o:p=83:17; the NMR data are shown in Figure 3 and Figure 4.
References:
CN113620811,2021,A Location in patent:Paragraph 0058-0061
![2-Butenenitrile, 4-[(2-chlorophenyl)(2-cyanoethyl)amino]-, (Z)- (9CI)](/CAS/20210305/GIF/101195-43-1.gif)
![2-Butenenitrile, 4-[(2-chlorophenyl)(2-cyanoethyl)amino]-, (E)- (9CI)](/CAS/20210305/GIF/101195-42-0.gif)
