ChemicalBook CAS DataBase List 3-(2-BENZOTHIAZOLYLTHIO)PROPIONIC ACID

3-(2-BENZOTHIAZOLYLTHIO)PROPIONIC ACID synthesis

14synthesis methods

Product Name:3-(2-BENZOTHIAZOLYLTHIO)PROPIONIC ACID
CAS Number:4767-00-4
Molecular formula:C10H9NO2S2
Molecular Weight:239.31

590-92-1 Synthesis

590-92-1
240 suppliers
$10.00/1g

149-30-4
646 suppliers
$5.00/25g

4767-00-4
67 suppliers
$7.00/5g

Yield: 100%

Reaction Conditions:

Stage #1:2-Mercaptobenzothiazole with potassium carbonate in tetrahydrofuran for 0.166667 h;Inert atmosphere;
Stage #2:3-Bromopropionic acid in tetrahydrofuran at 20;Inert atmosphere;

Steps:

Compound 3 was obtained in quantitative yield as an off-whitesolid. 2-Marcaptobenzothiazol (670 mg) was dissolved in THF(10 mL), potassium carbonate (1.1 g) was added, and the reaction wasstirred for 10 min under argon. Then 3-bromoproponic acid (910 mg)was added. The reaction was allowed to stir overnight at room temperatureunder argon. The reaction was neutralized with 2 M HCl and theproduct was extracted with DCM.

References:

Berkman, Clifford E.;Chen, Wei;Knight, Jessica Renee;Wang, Yingying;Xian, Ming;Xu, Shi [Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2021,vol. 247,art. no. 119072]