ETHYL 6-METHYL-4-(4-METHYLPHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE synthesis

9synthesis methods

Product Name:ETHYL 6-METHYL-4-(4-METHYLPHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE
CAS Number:299949-24-9
Molecular formula:C15H18N2O3
Molecular Weight:274.32

104-87-0 Synthesis

104-87-0
515 suppliers
$6.00/25g

141-97-9 Synthesis

141-97-9
797 suppliers
$5.00/25g

57-13-6 Synthesis

57-13-6
727 suppliers
$5.00/5g

ETHYL 6-METHYL-4-(4-METHYLPHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE

299949-24-9
17 suppliers
$28.60/25MG

Yield:299949-24-9 100%

Reaction Conditions:

with copper(II) bis(trifluoromethanesulfonate) in ethanol at 100; for 1 h;Microwave irradiation;Inert atmosphere;Biginelli reaction;

Steps:

Synthesis of dihydropyrimidinones

General procedure: Aldehyde (1.0 mmol), ethyl acetoacetate (1.0 mmol), urea (1.5 mmol), Cu(OTf)₂ (0.02 mmol), and EtOH (2 mL) were added to a microwave vial equipped with a magnetic stir bar. The reaction vessel was sealed and irradiated in a microwave reactor (CEM Discover system) at a temperature of 100 °C for 1 h at a maximum power of 200 W. The reaction mixture was cooled to room temperature overnight and the resulting precipitate was filtered and washed with H₂O and hexane. The identity and purity of the products were confirmed by TLC, high-resolution mass spectrometry, IR and ¹H and ¹³C NMR spectroscopy

References:

Pasunooti, Kalyan Kumar;Chai, Hua;Jensen, Chantel Nixon;Gorityala, Bala Kishan;Wang, Siming;Liu, Xue-Wei [Tetrahedron Letters,2011,vol. 52,# 1,p. 80 - 84] Location in patent:supporting information; experimental part

589-18-4 Synthesis