diethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate synthesis
- Product Name:diethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- CAS Number:21829-26-5
- Molecular formula:C19H22N2O6
- Molecular Weight:374.39
Yield:21829-26-5 97%
Reaction Conditions:
with ammonium acetate in ethanol at 60; for 0.333333 h;
Steps:
2.4 General Procedure for the1, 4-DHP Derivatives Synthesis
General procedure: In a 25mL round-bottomed fask, aldehyde (1mmol), ethyl acetoacetate (methyl acetoacetate, acetoacetate) (2mmol), ammonium acetate (1 mmol), and the catalyst (0.01 g,0.0016mmol) in 10ml ethanol were added. The reactionmixture was stirred at 60°C. After completion of the reactionwhich was traced by TLC, the catalyst was separated byusing an external magnet. The pure product was obtained bycrystallization of the crude material from ethanol.
References:
Rostamizadeh, Shahnaz;Daneshfar, Zahra;Khazaei, Ali [Catalysis Letters,2020,vol. 150,# 7,p. 2091 - 2114]
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