[R-(Z)]-N-[3-(dimethylamino)propyl]-12-hydroxy-9-octadecenamide synthesis
1synthesis methods
- Product Name:[R-(Z)]-N-[3-(dimethylamino)propyl]-12-hydroxy-9-octadecenamide
- CAS Number:20457-75-4
- Molecular formula:C23H46N2O2
- Molecular Weight:382.62
Yield:-
Steps:
1.a EXAMPLE 1
(a) Stage 1: Preparation of γ-Ricinoleamidopropyldimethylamine. 383 g (3.75 moles) of N,N-dimethylaminopropylamine were mixed with 1,043 g of commercial ricinoleic acid (3.5 moles) and heated to 180°-185° C. in a 5 liter reactor. The water of reaction is removed and the reaction is continued until a minimum acid value is attained. The product was then vacuum dried at 100°-105° C. at 50 mm vacuum. The amido-amide intermediate, γ-Ricinoleamidopropyldimethylamine, had the following properties:
References:
US4220581,1980,A