Imidazo[1,2-a]pyridine-2-carboxaldehyde, 6-methyl- (9CI) synthesis
- Product Name:Imidazo[1,2-a]pyridine-2-carboxaldehyde, 6-methyl- (9CI)
- CAS Number:202348-55-8
- Molecular formula:C9H8N2O
- Molecular Weight:160.17
926223-25-8
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Yield:-
Reaction Conditions:
with manganese(IV) oxide in dichloromethane at 20; for 92.5 h;Heating / reflux;
Steps:
334.c
Step (c) 6-Methylimidazo[l,2-a]pyridine-2-carbaldehydeTo a solution of (6-methylimidazo[l,2-a]pyridin-2-yl)methanol (0.84 g, 5.18 mmol) in DCM (15 ml) was added manganese dioxide (0.450 g, 5.18 mmol) and the reaction mixture was stirred under nitrogen at ambient temperature for 1.5 h and left to stand for a further 18 h. The reaction mixture was heated to reflux for 3 h before further manganese dioxide (2.5 g, 28.76 mmol) and DCM (15.00 ml) was added. The reaction mixture was
References:
WO2008/84223,2008,A2 Location in patent:Page/Page column 424-425