Yield:202134-57-4 92%

Reaction Conditions:

with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane at 20; for 50 h;Heating / reflux;

Steps:

1.1 Example 1; 1,1,1,3,3,3-hexafluoro-2-{4-[(phenylsulfonyl) methyl] phenyl} propan-2-ol; step 1; 2- [4-(bromomethyl) phenyl]-1,1,1, 3,3, 3-hexafluoropropan-2-ol

1,1, 1,3, 3, [3-HEXAFLUORO-2- (4-METHYLPHENYL) PROPAN-2-OL] (Lancaster, 25 g, 96.8 [MMOL)] was suspended [IN CC4 (125] mL). To the suspension was added NBS (17.2 g, 96. 7 mmol) and AIBN (20 mg, 0. [12MOL).] The reaction was heated at reflux for 2 h and cooled to ambient temperature over 48 h. The reaction mixture was filtered through Celite and [CONCENTRATED IN VACUO.] The solid was dissolved in Et20 and filtered. Concentration of the mother liquor afforded the title bromide as a yellow oil (30.0 g, 92%). MS (ES+) [M/Z] 338 [(MH+).

References:

WO2003/99775,2003,A1 Location in patent:Page 16