ChemicalBook CAS DataBase List 2-(Trifluoromethoxy)nitrobenzene

2-(Trifluoromethoxy)nitrobenzene synthesis

5synthesis methods

Product Name:2-(Trifluoromethoxy)nitrobenzene
CAS Number:1644-88-8
Molecular formula:C7H4F3NO3
Molecular Weight:207.11

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7783-56-4 Synthesis

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Yield: 62%

Reaction Conditions:

antimonypentachloride in tetrachloromethane

Steps:

2 nitrophenyl trifluoromethyl ether
nitrophenyl trifluoromethyl ether Using the same reactor setup as in Example 1, the reactor is charged with 3-nitrophenol (13.9 g, 0.1 mol), anhydrous carbon tetrachloride (38 ml, 0.39 mol), anhydrous antimony trifluoride (53.6 g, 0.3 mol) and a catalytic amount of antimony pentachloride (1 ml, 7.7 mmol). The reactor is then sealed and heated at 150° C (internal) with vigorous stirring for 5.5 hours. Subsequently, the reactor is opened and the contents neutralized with saturated NaHC03 The product is separated by steam distillation, and a 62 percent yield of the product is obtained.

References:

The Dow Chemical Company US4950802, 1990, A