ChemicalBook CAS DataBase List 2-PHENYL-2-PROPANOL

2-PHENYL-2-PROPANOL synthesis

13synthesis methods

Product Name:2-PHENYL-2-PROPANOL
CAS Number:617-94-7
Molecular formula:C9H12O
Molecular Weight:136.19

93-58-3 Synthesis

93-58-3
479 suppliers
$13.50/100 mL

676-58-4 Synthesis

676-58-4
282 suppliers
$15.00/25ml

617-94-7
188 suppliers
$6.00/1g

Yield:617-94-7 90%

Reaction Conditions:

with choline chloride;urea in tetrahydrofuran;water at 25; for 0.00555556 h;

Steps:

4.2. Synthesis of alcohols 3 by addition of organolithium or Grignard reagents to esters 1 in water or DES. General procedure
General procedure: In a 10mL Schlenk-like flask, aryl or alkyl ester 1 (0.5 mmol)was added to 1.0 mL of water or 1.0 g of DES, at room temperature in air,and the resulting mixture was vigorously stirred. A solution of the corresponding organolithium or Grignard reagent (2.5 equiv),handled under argon using conventional Schlenk techniques, was rapidly spread over the mixture under air and with vigorous stirring at room temperature to generate an emulsion. After 20 s, the reaction mixture was diluted with 2 mL of water, and then extracted with CPME (3.0 mL 3). The volatiles were removed under reduced pressure, and the residue was purified by column chromatography on silica gel (hexane/EtOAc, 8/2) to provide the desired product.

References:

Quivelli, Andrea F.;D'Addato, Giovanna;Vitale, Paola;García-álvarez, Joaquín;Perna, Filippo M.;Capriati, Vito [Tetrahedron,2021,vol. 81,art. no. 131898]

FullText

98-83-9 Synthesis