2-Pentanone, 1-bromo- synthesis
- Product Name:2-Pentanone, 1-bromo-
- CAS Number:817-71-0
- Molecular formula:C5H9BrO
- Molecular Weight:165.03
107-87-9
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Yield:817-71-0 65.79%
Reaction Conditions:
with bromine in methanol at -30 - 20;Inert atmosphere;
Steps:
4.40 Preparation 40
To a solution of pentan-2-one (4 g, 46.5 mmol) in MeOH (45 mL) cooled to -30oC under a nitrogen atmosphere, Br2 (2.32 mL, 46.5 mmol) was added drop-wise. The reaction mixture was allowed to warm to RT and stirred for 2 hrs, then concentrated in vacuo, diluted with ether and washed with aqueous saturated NaHCO3 solution followed by brine. The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by chromatography (eluted with PE : EA =100: 1) to afford 1-bromopentan-2-one (5 g, 65.79% yield) as a brown oil.
References:
WO2016/44792,2016,A1 Location in patent:Page/Page column 129; 130
109-67-1
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