2-Methylpyrimidine synthesis
- Product Name:2-Methylpyrimidine
- CAS Number:5053-43-0
- Molecular formula:C5H6N2
- Molecular Weight:94.11
1780-26-3
472 suppliers
$10.00/10g
5053-43-0
162 suppliers
$60.00/250mg
Yield:5053-43-0 28%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen;magnesium oxide in methanol;water at 20; under 1551.49 Torr; for 1 h;
Steps:
113.2 Step 2: 2-methylpyrimidine .
To a solution of 4,6-dichloro-2-methyl-pyrimidine (240 g, 1.47 mol) in methanol (1.32 1) and H20 (1.10 1) were added 10 % Pd/C (240 g) and MgO (240 g, 5.95 mol). The RM was stirred at rt under H2 atmosphere (30 psi) for 1 h. The mixture was filtered through Celite. The filtrate was extracted with DCM (4 x 1 1). The combined organic phases were distilled to remove DCM at 39 °C and methanol at 65 °C under 1 atm of pressure to give the title compound as a brown liquid. Y = 28 %. .H NMR (400 MHz, methanol-) δ 8.66 (d, J= 5 Hz, 2H), 7.29 (t, J= 5 Hz, 1H), 2.65 (s, 3H).
References:
NODTHERA LIMITED;BOCK, Mark G.;WATT, Alan Paul;PORTER, Roderick Alan;HARRISON, David WO2019/25467, 2019, A1 Location in patent:Paragraph 0694
4271-95-8
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$110.00/100mg
5053-43-0
162 suppliers
$60.00/250mg
93271-75-1
35 suppliers
$65.00/100mg
5053-43-0
162 suppliers
$60.00/250mg