ChemicalBook CAS DataBase List 2-Methyl-4-methoxybenzenamine

2-Methyl-4-methoxybenzenamine synthesis

11synthesis methods

Product Name:2-Methyl-4-methoxybenzenamine
CAS Number:102-50-1
Molecular formula:C8H11NO
Molecular Weight:137.18

5367-32-8
179 suppliers
$10.00/5g

102-50-1
224 suppliers
$6.00/5g

Yield:102-50-1 80%

Reaction Conditions:

with tetrahydroxydiboron;water at 80; for 8 h;

Steps:

2. General procedure for the reduction of nitroarenes
General procedure: Nitro aromatic (1.0 mmol), B2(OH)4 (5.0 equiv, 5.0 mmol), and H2O (3.0 mL) were added in a10 mL tube. The reaction mixture was stirred at 80 °C for 8 h. When the reaction was completemonitored by TLC, the mixture was cooled to room temperature, extracted with ethyl acetate (3 ×20 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, andconcentrated under reduced pressure. The residue was purified by silica gel columnchromatography.

References:

Chen, Danyi;Zhou, Yanmei;Zhou, Haifeng;Liu, Sensheng;Liu, Qixing;Zhang, Kaili;Uozumi, Yasuhiro [Synlett,2018,vol. 29,# 13,p. 1765 - 1768] Location in patent:supporting information

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27060-75-9 Synthesis