ChemicalBook CAS DataBase List 2-methyl-1-nitropropane

2-methyl-1-nitropropane synthesis

12synthesis methods

Product Name:2-methyl-1-nitropropane
CAS Number:625-74-1
Molecular formula:C4H9NO2
Molecular Weight:103.12

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Yield: 95.6%

Reaction Conditions:

with ammonia;dihydrogen peroxide in propan-1-ol;water at 85; under 2250.23 Torr;

Steps:

22
A mixture of isobutyraldehyde oxime 100 gAnd propanol 260g (water content 35%)Mixed by the mixer with a metering pump A,Hydrogen peroxide (content of 50%) 102g with metering pump B4 g of a catalyst with a titanium-zirconium doped microporous-mesoporous composite catalyst (silicon metal ratio of 65)Ammonia 0.6g reactor, the temperature of 85 , pressure 0.3MPa.The membrane-separated reaction supernatant is removed by desolvation1-nitroisobutane, 98.4 g, purity 99.1%.The yield was 95.6%, and the unreacted oxime was returned by the recovery to continue the oxidation reaction.

References:

Nanjing Tech University;Zhu Hongjun;Chu Qingyan;Song Guangliang;Liu Rui;He Guangke;Huang Cheng CN106631809, 2017, A Location in patent:Paragraph 0059; 0060