ChemicalBook CAS DataBase List 2-methoxypropionic acid

2-methoxypropionic acid synthesis

12synthesis methods

Product Name:2-methoxypropionic acid
CAS Number:4324-37-2
Molecular formula:C4H8O3
Molecular Weight:104.1

124-41-4 Synthesis

124-41-4
692 suppliers
$12.00/25g

598-72-1 Synthesis

598-72-1
347 suppliers
$15.00/25g

4324-37-2
70 suppliers
$9.00/1g

Yield: 99%

Reaction Conditions:

in methanol at 50;

Steps:

A.1
Sodium methoxide in methanol (25%, 16 mL) was added to a stirred solution of 2- bromopropionic acid (19.6 mmol) in methanol (5 mL) under nitrogen. The reaction was heated at 50 ⁰C under nitrogen overnight. The reaction was then concentrated under vacuum. The residue was brought to pH 1 by the addition of 1 N aqueous HCl and this solution was then extracted with ethyl acetate three times (70 mL, 25 mL, 10 mL). The combined organic layer was dried (Na₂SO₄) and then concentrated under vacuum to yield the title compound as a colorless oil 2.04 g (99%) which was of sufficient purity to be used without purification. ¹H NMR (CD₃OD) δ 3.67 (q, IH), 3.33 (s, 3H), and 1.33 ppm (d, 3H).

References:

BAYER PHARMACEUTICALS CORPORATION WO2006/96338, 2006, A1 Location in patent:Page/Page column 41

27871-49-4 Synthesis