2-Iodobenzyl bromide synthesis
- Product Name:2-Iodobenzyl bromide
- CAS Number:40400-13-3
- Molecular formula:C7H6BrI
- Molecular Weight:296.93
615-37-2
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$5.00/5g
40400-13-3
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$21.00/1G
Yield:40400-13-3 69%
Reaction Conditions:
with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethaneReflux;
Steps:
1-(bromomethyl)-2-iodobenzene
A mixture of l-iodo-2-methylbenzene (0.5 g, 2.3 mmol), N-bromosuccinimide (0.7 g, 3.7 mmol) and 2,2'-azobisisobutyronitrile (0.02 g, 0.1 mmol) in tetrachloromethane (10 mL) was heated at reflux until the reaction was completed (tic control). After cooled down to the ambient temperature the reaction mixture was quenched with water and water layer was extracted with dichloromethane. Combined organic phases were washed with sodium hydrocarbonate, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel; hexane/ethyl acetate 9: 1) to give l-(bromomethyl)-2-iodobenzene (0.5 g) as yellowish oil; yield 69%.
References:
SELVITA S.A.;RZYMSKI, Tomasz;MILIK, Mariusz;BRZOZKA, Krzysztof;FABRITIUS, Charles-Henry;KUCWAJ-BRYSZ, Katarzyna;KULESZA, Urszula;WINCZA, Ewelina;DREAS, Agnieszka;GALEZOWSKI, Michal WO2017/68064, 2017, A1 Location in patent:Page/Page column 188; 189
5159-41-1
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40400-13-3
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$21.00/1G
18698-96-9
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$5.00/250mg
40400-13-3
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624-31-7
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$9.00/25g
40400-13-3
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$21.00/1G
