ChemicalBook CAS DataBase List 2-Hydroxybenzimidazole

2-Hydroxybenzimidazole synthesis

14synthesis methods

Product Name:2-Hydroxybenzimidazole
CAS Number:615-16-7
Molecular formula:C7H6N2O
Molecular Weight:134.14

95-54-5 Synthesis

95-54-5
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$9.00/1g

57-13-6 Synthesis

57-13-6
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$5.00/5g

615-16-7
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$8.00/10g

Yield:615-16-7 94%

Reaction Conditions:

with sulfated polyborate at 120; for 1.5 h;

Steps:

General procedure for the synthesis of (un)symmetrical 1,3-disubstituted ureas and 1H-benzimidazol-2(3H)-ones
General procedure: A mixture of amine (4 mmol or 2 mmol), or substituted OPDA (2 mmol), urea (2.4mmol), or N-phenylurea (2 mmol) and sulfated polyborate (10 wt%) was heated at 120°C in an oil bath. The reaction was monitored by thin layer chromatography. After completion of the reaction, the mixture was cooled to room temperature and quenched by water (5 mL); solid precipitated was filtered at vacuum pump, washed with water (3×5 mL), dried under vacuum and recrystallized from ethanol to afford the pure product.

References:

Rekunge, Deelip S.;Khatri, Chetan K.;Chaturbhuj, Ganesh U. [Tetrahedron Letters,2017,vol. 58,# 45,p. 4304 - 4307] Location in patent:supporting information

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