ChemicalBook CAS DataBase List 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE

2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE synthesis

5synthesis methods

Product Name:2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE
CAS Number:42487-72-9
Molecular formula:C9H15N3O
Molecular Weight:181.23

18240-93-2
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141-97-9 Synthesis

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2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE

42487-72-9
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$23.00/100mg

Yield: 86.1%

Reaction Conditions:

at 130; for 0.00555556 h;

Steps:

3
The second microreactor was thermostated at 130°C, and 251.7g of guanidine solution and131g (1.0 mol) ethyl acetoacetate was pumped into the microreactor at the same time at a flow rate ratio of 1.9:1,The residence reaction time of the materials in the microreactor is 20s. After all the reaction liquid is received, 30mL water is used to wash and separate the phases.After the organic phase is distilled at -0.09MPa to recover the solvent, a 98.0% content is obtainedThe 2-diethylamino-6-methyl-4-hydroxy-pyrimidine was 159.0 g, and the yield was 86.1% (calculated as cyanamide).

References:

Hunan Subo Biological Co., Ltd.;Wang Yu;Yang Bin CN111423383, 2020, A Location in patent:Paragraph 0012; 0028-0029