成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER
741709-62-6

2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER synthesis

1synthesis methods
-

Yield:741709-62-6 1.2g

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 100; for 2 h;

Steps:

188.a Example 188 (S)-4-(4-(3-(1-Cyanopyrrolidin-2-yl)-1,2,4-oxadiazol-5-yl)pyrimidin-2-yl)picolinonitrile
Step a. To a solution of 4-chloro-2-pyridinecarbonitrile (0.700 g, 5.05 mmol) in 1,4-dioxane (14 ml) were added dis(pinacolato)diboron (1.920 g, 7.57 mmol) and potassium acetate (1.53 g, 15.7 mmol) at rt. The reaction mixture was degassed for 15 min before addition of Pd(dppf)C1-2 (0.184 g, 0.252 mmol). The reaction was heated at 100° C. for 2 h. The resulting reaction mixture was cooled to rt, combined with one other batch prepared on the same scale by an identical method, diluted with water (40 ml) and extracted with EtOAc (2×40 ml). The combined organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (5% EtOAc in hexane) yielding 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile (1.200 g, 5.22 mmol). LCMS: Method C, 1.136, MS: ES+149.20 [M-81]

References:

MISSION THERAPEUTICS LIMITED;JONES, Alison;KEMP, Mark Ian;STOCKLEY, Martin Lee;WOODROW, Michael D. US2020/331888, 2020, A1 Location in patent:Paragraph 1006-1007

2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER Related Search: