ChemicalBook CAS DataBase List 2-Chloropyrazine

2-Chloropyrazine synthesis

10synthesis methods

Product Name:2-Chloropyrazine
CAS Number:14508-49-7
Molecular formula:C4H3ClN2
Molecular Weight:114.53

24387-68-6 Synthesis

24387-68-6
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14508-49-7
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Yield:14508-49-7 95.4%

Reaction Conditions:

with thionyl chloride;N-ethyl-N,N-diisopropylamine in chloroform at 65; for 2 h;Reagent/catalyst;

Steps:

1.c; 4-5

(c) Add 0.05 mol of dichlorosulfoxide, 0.5 mmol N,N-diisopropylethylamine and chloroform to a three-necked flask, and raise the temperature to 65°C,After adding 0.05mol of 2-hydroxypyrazine sodium salt and holding the reaction for 2h,The reaction solution was cooled to room temperature, and then slowly poured into an appropriate amount of ice water for hydrolysis,Then adjust the pH to 7-8 with 1N sodium hydroxide solution and distill,Fractions from 98 to 101°C were collected. Extract the resulting fraction,The lower product 2-chloropyrazine 5.46g was separated with a yield of 95.4%.

References:

CN111004187,2020,A Location in patent:Paragraph 0034; 0038-0039; 0047-0052

98-97-5 Synthesis