Yield:-

Reaction Conditions:

with thionyl chloride in dichloromethane;toluene;

Steps:

3 2-(Chloromethyl)imidazole hydrochloride

2-(Chloromethyl)imidazole hydrochloride To a solution of 30 ml of toluene containing 3 ml of thionyl chloride was added 970 mg of 2-(hydroxymethyl)imidazole hydrochloride. The reaction mixture was heated to the refluxing temperature of the solvent for 3 hours, cooled and concentrated to dryness under reduced pressure. The residue was resuspended in methylene chloride treated with 2 ml of thionyl chloride and refluxed for 1 hour more. Concentration in vacuo afforded the title compound as a white solid (1.2 g).

References:

US5218115,1993,A