ChemicalBook CAS DataBase List 2-CHLORODIBENZO-P-DIOXIN

2-CHLORODIBENZO-P-DIOXIN synthesis

8synthesis methods

Product Name:2-CHLORODIBENZO-P-DIOXIN
CAS Number:39227-54-8
Molecular formula:C12H7ClO2
Molecular Weight:218.64

31928-44-6 Synthesis

31928-44-6
179 suppliers
$6.00/1g

120-80-9 Synthesis

120-80-9
505 suppliers
$13.00/25g

39227-54-8
7 suppliers
$1478.40/10ML

Yield:39227-54-8 70%

Reaction Conditions:

with copper;potassium carbonate in N,N-dimethyl-formamide at 150; for 24 h;

Steps:

1

3.15 g (10 mmol) of 2-bromo-4-chloro-1-iodinebenzene, 1.10 g (10 mmol) of 1,2-benzenediol, 0.3 g (5 mmol) of Cu, and 2.76 g (20 mmol) of K₂CO₃were dissolved in 50 ml of DMF, and then, the mixed solution was stirred at a temperature of 150° C. for 24 hours. After the reaction solution was cooled to room temperature, 60 ml of water was added thereto, and an extraction process was performed thereon three times by using 60 ml of ethylether. An organic layer collected therefrom was dried by using magnesium sulfate, and residual obtained by evaporating a solvent therefrom was separation-purified by silica gel chromatography to obtain 1.526 g (yield: 70%) of Intermediate A.

References:

US2018/13076,2018,A1 Location in patent:Paragraph 0351; 0352