![66909-30-6](/CAS/GIF/66909-30-6.gif)
2-Chloro-5-methylpyridine-3-carboxylic acid synthesis
- Product Name:2-Chloro-5-methylpyridine-3-carboxylic acid
- CAS Number:66909-30-6
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58
![2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER](/StructureFile/ChemBookStructure20/GIF/CB8791179.gif)
65169-43-9
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$49.00/100mg
![2-Chloro-5-methylpyridine-3-carboxylic acid](/CAS/GIF/66909-30-6.gif)
66909-30-6
116 suppliers
$8.00/250mg
Yield: 94%
Reaction Conditions:
with methanol;sodium hydroxide;water at 20; for 2 h;
Steps:
32
INTERMEDIATE 322-Chloro-5-methylnicotinic acid; Intermediate 31 (0.38g, 1.81mmol) was dissolved in MeOH (2ml) and 2N NaOH solution was added (1.81ml, 3.62mmol) and the mixture stirred at room temperature for 2 hours. The reaction mixture was concentrated to dryness and the residue redissolved in EtOAc/
References:
LABORATORIOS ALMIRALL, S.A. WO2008/77639, 2008, A1 Location in patent:Page/Page column 26-27
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
129 suppliers
$175.00/23402
![2-Chloro-5-methylpyridine-3-carboxylic acid](/CAS/GIF/66909-30-6.gif)
66909-30-6
116 suppliers
$8.00/250mg
![2-Chloro-5-methylpyridine](/CAS/GIF/18368-64-4.gif)
18368-64-4
442 suppliers
$10.00/1g
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
129 suppliers
$175.00/23402
![2-Chloro-5-methylpyridine-3-carboxylic acid](/CAS/GIF/66909-30-6.gif)
66909-30-6
116 suppliers
$8.00/250mg
![2-Chloro-5-methylpyridine](/CAS/GIF/18368-64-4.gif)
18368-64-4
442 suppliers
$10.00/1g
![2-Chloro-5-methylpyridine-3-carboxylic acid](/CAS/GIF/66909-30-6.gif)
66909-30-6
116 suppliers
$8.00/250mg