2-CHLORO-4-SULFAMOYLANILINE synthesis
- Product Name:2-CHLORO-4-SULFAMOYLANILINE
- CAS Number:53297-68-0
- Molecular formula:C6H7ClN2O2S
- Molecular Weight:206.65
63-74-1
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53297-68-0
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Yield: 95%
Reaction Conditions:
with N-chloro-succinimide in tetrahydrofuran at 40; for 25 h;Solvent;Temperature;
Steps:
4.1 The first step, synthesis of compound 2
Under anhydrous and anaerobic conditions,Dissolve 1 mmol of sulfanilamide in 12 mL of tetrahydrofuran.Then add 2mmol NCS powder,The reaction was carried out at 40 °C for 25 h.The solvent was distilled off, the residue was extracted with 30 mL of ether, and the organic layer was washed with 5 mL of saturated potassium carbonate solution and 5 mL of saturated saline.The organic layer was dried over anhydrous sodium sulfate and subjected to column chromatography (dichloromethane:ethyl acetate 7:1).188 mg of pale yellow powder was obtained in a yield of 95%.
References:
Dalian University of Technology;Liu Jianhui;Chang Renyi;Min Xiangting CN107400060, 2017, A Location in patent:Paragraph 0011; 0029; 0030; 0036; 0037; 0043-0044; 0050-0051
68252-72-2
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95-51-2
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53297-68-0
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