2-CHLORO-4-METHYLBENZONITRILE synthesis
- Product Name:2-CHLORO-4-METHYLBENZONITRILE
- CAS Number:7390-42-3
- Molecular formula:C7H13NS
- Molecular Weight:143.25
1122-56-1
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$20.00/5g
7390-42-3
21 suppliers
$85.00/250mg
Yield:7390-42-3 97%
Reaction Conditions:
with Lawessons reagent in toluene at 20; for 0.15 h;
Steps:
33.1 Step 1
To a mixture of 527a (7 g, 0.55 mol) in toluene (100 mL) was added Lawesson Reagent (22.3 g, 55 mmol). The mixture was allowed to stir at room temperature for about 15 hours. The reaction mixture was concentrated in vacuo, and the resulting residue was purified using flash column chromatography on silica gel, eluting with petroleum ether: ethyl acetate (15/1-5/1) to provide 527b (8 g, 97 %)
References:
WO2014/110705,2014,A1 Location in patent:Page/Page column 144
766-05-2
143 suppliers
$13.43/1gm:
7390-42-3
21 suppliers
$85.00/250mg