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ChemicalBook CAS DataBase List 2-Chloro-3-Bromo-5-Hydroxypyridine
130115-85-4

2-Chloro-3-Bromo-5-Hydroxypyridine synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 94 percent / POCl3, quinoline / 2 h / 120 °C
2: 87 percent / Fe, AcOH / H2O / 2 h / below 50 deg C
3: 1) HBF4, NaNO2 / 1)water, 0 deg C, 1 h, 2) 70 deg C, 1 h
4: 98 percent / 2 N KOH / 0.5 h / 5 °C

References:

Koch;Schnatterer [Synthesis,1990,# 6,p. 499 - 501]

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