2-CHLORO-3,6-DIFLUOROBENZAMIDE synthesis
- Product Name:2-CHLORO-3,6-DIFLUOROBENZAMIDE
- CAS Number:261762-40-7
- Molecular formula:C7H4ClF2NO
- Molecular Weight:191.56
261762-40-7
22 suppliers
$29.00/1g
886501-33-3
42 suppliers
$34.50/1g
Yield:-
Reaction Conditions:
Stage #1: 2-chloro-3,6-difluorobenzamidewith trichlorophosphate at 95; for 2 h;
Stage #2: with potassium carbonate in water;ethyl acetate;
Steps:
2-ChIoro-3,6-difluorobenzoαitriIe2-Chloro-3,6-difluorobenzamide (0.80 g, 4.18 mmol) in POCl3 (12 mL) was heated for 2 h at 95 0C. The sol. was cooled and the excess of POCl3 was removed by distillation under reduced pressure. The residue was diluted with EtOAc and aq. 10% K2CO3 was cautiously added. The layers were separated and the org. phase was washed with water (2x), and brine. The org. extracts were dried over MgSO4, filtered, and the solvent were removed under reduced pressure to yield the title compound (0.46 g) that was not further purified.
References:
WO2006/63610,2006,A1 Location in patent:Page/Page column 15