ChemicalBook CAS DataBase List 2-Bromomethyl-1,3-dioxolane

2-Bromomethyl-1,3-dioxolane synthesis

9synthesis methods

Product Name:2-Bromomethyl-1,3-dioxolane
CAS Number:4360-63-8
Molecular formula:C4H7BrO2
Molecular Weight:167

107-21-1 Synthesis

107-21-1
1330 suppliers
$10.00/25g

75-07-0 Synthesis

75-07-0
422 suppliers
$14.00/5mL

4360-63-8
303 suppliers
$5.00/5g

Yield:4360-63-8 79.2%

Reaction Conditions:

Stage #1:ethylene glycol;acetaldehyde at 20; for 0.5 h;Large scale;
Stage #2: with bromine at 0 - 3; for 3.5 h;Large scale;Temperature;

Steps:

1.b b. Preparation of bromoacetaldehyde ethylene glycol
To a reaction vessel, 10.326kg (166.3mol) of ethylene glycol was added with 3.66 Kg (83.185mol) of freshly distilled acetaldehyde and stirred slowly at room temperature for 30 mins. 14.622 Kg (91.504 mol) of bromine was added dropwise, after the dropwise addition, the reaction was carried out at 0-3°C for 3.5h, and the fraction was distilled under reduced pressure. The fractions (3.6 kPa) and 11.002 Kg (65.883 mol) of 80-82 ° C were collected and identified as bromoacetaldehyde ethylene glycol, the yield is 79.2%, the content is more than 95%.

References:

Beijing Yifang Biological Technology Co., Ltd.;Wang, Jiao;Shi, Qingdong CN105418612, 2016, A Location in patent:Paragraph 0028; 0039; 0040

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7252-83-7 Synthesis