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ChemicalBook CAS DataBase List 2-Bromo-6-fluoropyridine
144100-07-2

2-Bromo-6-fluoropyridine synthesis

4synthesis methods
-

Yield:-

Reaction Conditions:

with potassium fluoride

Steps:

35 Preparation by method B:

100 g (422.10 mmol) of 2,6-dibromopyridine, 36.79 g (633.15 mmol) of potassium fluoride and 11.16 g of 18-crown-6 are heated in a distillation apparatus 190° C. under vacuum (200 mbar), and the reaction product is distilled off. Repeated purification by distillation gives 43.90 g of 2-bromo-6-fluoropyridine having a boiling point of 70° C. at 15 mbar. STR66

References:

US5630962,1997,A

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