ChemicalBook CAS DataBase List 2-Bromo-2-phenylacetic acid

2-Bromo-2-phenylacetic acid synthesis

8synthesis methods

Product Name:2-Bromo-2-phenylacetic acid
CAS Number:4870-65-9
Molecular formula:C8H7BrO2
Molecular Weight:215.04

103-82-2
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$22.19/5g

4870-65-9
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$8.00/1g

Yield:4870-65-9 95%

Reaction Conditions:

with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane at 77; for 2 h;

Steps:

1.1 (1) compound1a synthesis:
30.0 ml dry two neck bottles and a condensation device, adding 2-phenyl acetic acid (376 mg, 2 . 77mmol), N-bromo succinimide (540 mg, 3 . 05mmol) and carbon tetrachloride (5.5 ml), stirring, add azodiisobutanenitrile (23 mg, 0 . 14mmol), 77 °C heating to reflux, the reaction under stirring 2 hours, by nuclear magnetic resonance spectral (¹HNMR) monitoring reaction 2-phenyl acetic acid dematerialised, natural cooling to room temperature, the normal hexane (10.0 ml) in two neck bottle to dilute and to filter and, revolving off a solvent, a silica gel column (eluent: n-hexane and ethyl ether volume ratio [...] 2 1) to obtain white solid 2-bromo-2-benzoic acid1a (95% yield).

References:

Henan University;Jiang, Zhiyong;Zhu, Bo;Zhao, Xiaowei;Jiao, Lihui;Li, Jiangtao CN105384703, 2016, A Location in patent:Paragraph 0014

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2835-06-5 Synthesis