ChemicalBook CAS DataBase List 2-Bromo-2-methylpropanamide

2-Bromo-2-methylpropanamide synthesis

5synthesis methods

Product Name:2-Bromo-2-methylpropanamide
CAS Number:7462-74-0
Molecular formula:C4H8BrNO
Molecular Weight:166.02

To a vigorously stirred solution of 2-bromo-2-methylpropanoyl bromide (11 mL) in light petroleum ether (250 mL) at 0 °C was added in portions of aqueous ammonia (50 mL). Stirring was continued for a further 30 min, and the resulting precipitate was collected and washed with water (2 x 50 mL) to give 2-Bromo-2-methylpropanamide as a white solid (14.1 g, 96 percent).

20769-85-1
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7462-74-0
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Yield:7462-74-0 96%

Reaction Conditions:

in ammonium hydroxide;Petroleum ether

Steps:

5.b b
b 2-Bromo-2-methylpropanamide To a vigorously stirred solution of 2-bromo-2-methylpropanoyl bromide (11 mL) in light petroleum ether (250 mL) at 0 ° C. was added in portions aqueous ammonia (50 mL). Stirring was continued for a further 30 min, and the resulting precipitate was collected and washed with water (2*50 mL) to give the title compound as a white solid (14.1 g, 96%) which was directly used in the next step without purification.

References:

3-Dimensional Pharmaceuticals, Inc. US5891909, 1999, A

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