ChemicalBook CAS DataBase List 2-Bromo-1-phenyl-pentan-1-one

2-Bromo-1-phenyl-pentan-1-one synthesis

10synthesis methods

Product Name:2-Bromo-1-phenyl-pentan-1-one
CAS Number:49851-31-2
Molecular formula:C11H13BrO
Molecular Weight:241.12

2-bromo-1-phenylpentan-1-one is an organic synthesis intermediate and pharmaceutical intermediate, mainly used as valerophenone (sc-237408) derivative. It can be synthesized by valerophenone Ketone and sodium bromide obtained from the reaction.

1009-14-9 Synthesis

1009-14-9
405 suppliers
$6.00/5g

49851-31-2
152 suppliers
$140.00/100mg

Yield:49851-31-2 95%

Reaction Conditions:

with hydrogenchloride;dihydrogen peroxide;sodium bromide in water at 20;

Steps:

1

At room temperature, 16.2 g (0.1 mol) of valerophenone and 30.9 g (0.3 mol) of sodium bromide were added to a 500 mL round bottom flask, and after stirring,Add 24g (0.2mol) of 30% hydrochloric acid, and slowly add 19g (0.15mol) of 30% hydrogen peroxide. After the end of the addition, continue the reaction for 1~2h.After the end of the TLC monitoring reaction, the stirring was stopped, and the layers were allowed to stand, washed with saturated sodium carbonate and saturated brine, and the organic phases were combined.After concentration, it was dried over anhydrous magnesium sulfate to give α-bromovalerophenone as a bright yellow oily liquid, yield 95%, purity 98% (HPLC method).

References:

CN108276264,2018,A Location in patent:Paragraph 0016