2-Amino-5-nitrobenzotrifluoride synthesis
- Product Name:2-Amino-5-nitrobenzotrifluoride
- CAS Number:121-01-7
- Molecular formula:C7H5F3N2O2
- Molecular Weight:206.12
Yield:121-01-7 50.2 g
Reaction Conditions:
with fac-tris(2-phenylpyridinato-N,C2')iridium(III);potassium carbonate in 1,2-dichloro-ethane at 20; for 24 h;Inert atmosphere;
Steps:
2.I I. Trifluoromethyl substitution reaction
xAdd 50g of 4-nitroaniline and 150g of 1,2-dichloroethane as a solvent to a reaction device protected by inert gas argon, and add the complex of iridium-tris(2-phenylpyridine) (fac-Ir(ppy)3) 3.8g is used as a catalyst, then 20g K2CO3 is added, 19.4g trifluoroiodomethane is mixed with 50g 1,2-dichloroethane first, and then slowly added. React for 24h at room temperature under blue light. After filtration and concentration, 50.2 g of 2-amino-5-nitrobenzotrifluoride was obtained.
References:
CN112225676,2021,A Location in patent:Paragraph 0129; 0130-0133
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121-01-7
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