
2-Amino-5-Methyl-Benzonitrile synthesis
- Product Name:2-Amino-5-Methyl-Benzonitrile
- CAS Number:5925-93-9
- Molecular formula:C8H8N2
- Molecular Weight:132.16

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5925-93-9
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Yield: 99%
Reaction Conditions:
Stage #1:2-nitro-5-methylbenzonitrile with hydrogenchloride;tin(ll) chloride in ethanol;water at 20 - 30; for 1 h;
Stage #2: with sodium hydroxide in ethanol;water; pH=7
Steps:
14.b
5-Methyl-2-nitrobenzonitrile (1.92 g, 11.84 mmol) was added in portions to a stirred solution of SnCl2 (11.22 g, 59.2 mmol) in conc. HCl (12 mL) and EtOH (12 mL). The reaction temperature was maintained at 20-30° C. using an ice bath. The reaction mixture was then stirred at room temperature for 1 h and poured into an ice cold aqueous solution of NaOH (6N, app. 30 mL) to neutralize to pH7. The product was extracted into EtOAc, washed with brine, dried over MgSO4 and concentrated to provide the title product (1.56 g, 99%) as a yellow-brown solid. 1H NMR (400 MHz, DMSO-d6) δ 2.21 (s, 3H), 5.79 (bs, 2H), 6.68-6.71 (d, 1H), 7.10-7.13 (dd, 1H), 7.15 (s, 1H). 13C NMR (DMSO-d6) δ 20.13, 93.99, 116.12, 118.94, 125.38, 132.32, 135.76, 150.21. MS 133 (MH+).
References:
SENOMYX, INC. US2008/306053, 2008, A1 Location in patent:Page/Page column 60

29289-13-2
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544-92-3
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5925-93-9
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$13.00/250mg

583-68-6
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544-92-3
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5925-93-9
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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5925-93-9
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5925-93-9
135 suppliers
$13.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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