2-AMINO-5-BROMOPHENOL synthesis
- Product Name:2-AMINO-5-BROMOPHENOL
- CAS Number:38191-34-3
- Molecular formula:C6H6BrNO
- Molecular Weight:188.02
16394-40-4
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38191-34-3
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Yield:38191-34-3 89%
Reaction Conditions:
Stage #1:N-(4-bromo-2-hydroxyphenyl)acetamide with hydrogenchloride;water in ethanol at 100; for 3 h;
Stage #2: with sodium carbonate in ethanol;water
Steps:
INTERMEDIATE B3 2-Amino-5-bromophenol A suspension of iV-(4-bromo-2-hydroxyphenyl)acetamide (Intermediate B2; 1.35 g, 5.87 mmol) in EtOH (30 mL) and 3 M HCl (30 mL) was heated to 100 0C (reflux) for 3 h. To the mixture was then added 1 M Na2CO3 (45 mL) and the ethanol was removed under reduced pressure. The residue was extracted with DCM (3 x 250 mL), dried and concentrated. Yield 988 mg (89%). Analytical HPLC: purity 100% (System A); LRESIMS (ESI+) m/z = 188/190 (M+H)+.
References:
INOVACIA AB WO2009/150144, 2009, A1 Location in patent:Page/Page column 138
27684-84-0
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591-20-8
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