2-Amino-3-bromo-5-(trifluoromethyl)-pyridine synthesis
- Product Name:2-Amino-3-bromo-5-(trifluoromethyl)-pyridine
- CAS Number:79456-30-7
- Molecular formula:C6H4BrF3N2
- Molecular Weight:241.01
74784-70-6
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79456-30-7
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Yield:79456-30-7 94.17%
Reaction Conditions:
with N-Bromosuccinimide in tetrahydrofuran at 0 - 20; for 1 h;Temperature;Solvent;
Steps:
57; 63 3-Bromo-5-(trifluoromethyl)pyridin-2-amine
To a solution of 5- (trifluoromethyl)pyridin-2-amine (10 g, 61.69 mmol) in THF (100 mL) was added NBS (11.53 g, 64.77 mmol) portionwise at 0 °C and the mixture was stirred at 20 °C for 1 h. The mixture was concentrated under vacuum and purified by silica gel column chromatography to give 3-bromo- 5-(trifhioromethyl)pyridin-2-amine (14 g, 58.09 mmol, 94.17% yield).
References:
WO2020/219871,2020,A1 Location in patent:Paragraph 00499; 00529
79456-29-4
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74784-70-6
330 suppliers
$5.00/1g
79456-30-7
127 suppliers
$6.00/250mg