ChemicalBook CAS DataBase List 2-AMINO-1-METHYLBENZIMIDAZOLE

2-AMINO-1-METHYLBENZIMIDAZOLE synthesis

11synthesis methods

Product Name:2-AMINO-1-METHYLBENZIMIDAZOLE
CAS Number:1622-57-7
Molecular formula:C8H9N3
Molecular Weight:147.18

934-32-7 Synthesis

934-32-7
325 suppliers
$6.00/5g

74-88-4
348 suppliers
$15.00/10g

1622-57-7
128 suppliers
$37.00/1g

Yield: 90%

Reaction Conditions:

Stage #1:1H-benzimidazol-2-amine with potassium hydroxide in acetone at 20; for 0.166667 h;
Stage #2:methyl iodide in acetone for 0.166667 h;Cooling with ice;

Steps:

2.2 Step 2: 1-Methyl-1H-benzo[d]imidazol-2-amine
In a 50 mL single-mouth pear-shaped flask, 0.55 g (4.1 mmol) of 1H-benzo[d]imidazol-2-amine was dissolved in 15 mL of acetone, 0.46 g (8.2 mmol) of potassium hydroxide powder was added, and stirred at room temperature for 10 min, and moved to In an ice water bath, 0.28 mL of methyl iodide (4.5 mmol) was added dropwise, stirred for 10 min, and the reaction was complete by TLC. After moving to room temperature, 15 mL of H2O was added, the solvent was removed, and the mixture was extracted with EA (10 mL*3). The organic phase was combined, concentrated, and purified on silica gel column (eluent: PE: EA=PE~50:1) Fluorescent brown viscous liquid 550 mg, yield 90%

References:

Guangzhou Anyanren Pharmaceutical Technology Co., Ltd.;Xie Dexun;Li Quanwei;Xue Weicai;Liu Hui CN108912095, 2018, A Location in patent:Paragraph 0194; 0198; 0199