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1247508-22-0

2-amino-1-(4-chloro-3-fluorophenyl)ethan-1-ol synthesis

1synthesis methods
5527-95-7 Synthesis
4-Chloro-3-fluorobenzaldehyde

5527-95-7
266 suppliers
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2-amino-1-(4-chloro-3-fluorophenyl)ethan-1-ol

1247508-22-0
6 suppliers
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: zinc(II) iodide / neat (no solvent) / 0 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C

References:

Keith, John M.;Hawryluk, Natalie;Apodaca, Richard L.;Chambers, Allison;Pierce, Joan M.;Seierstad, Mark;Palmer, James A.;Webb, Michael;Karbarz, Mark J.;Scott, Brian P.;Wilson, Sandy J.;Luo, Lin;Wennerholm, Michelle L.;Chang, Leon;Rizzolio, Michele;Chaplan, Sandra R.;Breitenbucher, J. Guy [Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,# 5,p. 1280 - 1284]