2,6-DINITRO-3-HYDROXYPYRIDINE synthesis
- Product Name:2,6-DINITRO-3-HYDROXYPYRIDINE
- CAS Number:15128-91-3
- Molecular formula:C5H3N3O5
- Molecular Weight:185.09
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Yield:15128-91-3 51%
Reaction Conditions:
with HNO3;acetic anhydride at 0 - 20; for 4 h;
Steps:
51.01 Step-01: Preparation of 2,6-dinitropyridin-3-ol
To a pre-mixture solution of acetic anhydride (14 mL) and nitric acid (6.2 mL) was added a solution of 2-nitropyridin-3-ol (5 g) drop wisely at 0°C temperature. Resulting solution was stirred at 0°C for 2 h followed by stirring at room temperature for additional 2 h. After completion of the reaction (monitored by TLC), the reaction mass was quenched with ice water and extracted with dichloromethane (3 x 150 mL). The combined organic layer was dried over anhydrous sodium sulfate, evaporated under reduced pressure to obtain a crude. The crude was triturated with -pentane followed by drying under reduced pressure to afford 2,6-dinitropyridin-3-ol (3.4 g, 51%) as a yellow solid.*H NMR (400 MHz, DMSO-rf6): d 10.72 (b s, 1H), 8.53 (d, 1H), 7.89-7.85 (m, 1H).
References:
WO2022/180560,2022,A1 Location in patent:Page/Page column 126
15128-82-2
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108-24-7
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