ChemicalBook CAS DataBase List 2,6-Dichloroisonicotinonitrile

2,6-Dichloroisonicotinonitrile synthesis

7synthesis methods

Product Name:2,6-Dichloroisonicotinonitrile
CAS Number:32710-65-9
Molecular formula:C6H2Cl2N2
Molecular Weight:173

89281-13-0
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$21.75/1g

32710-65-9
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Yield: 99%

Reaction Conditions:

with tetraethylammonium chloride;trichlorophosphate at 80; for 24 h;

Steps:

General preparation of carbonitriles 8 and 14.
General procedure: The appropriate carboxamide 7 or 13 (189 mg, 0.99 mmol) was subjected to catalytic amounts of tetraethylammonium chloride (5% w/w) and POCl3 (5 ml) and heated under reflux at 80°C for 24 h. Excess POCl3 was removed in vacuo to leave a crude residue which was diluted with dichloromethane (10 ml) and filtered. The filtrate was washed successively with saturated aqueous K2CO3 (2 x 5 ml) and distilled water (5 ml). After drying over anhydrous Na2SO4, the solvent was evaporated to yield carbonitrile 8 or 14 which was sufficiently pure for use in the next reaction without purification.

References:

Changunda, Charles R.K.;Rousseau, Amanda L.;Basson, Adriaan E.;Bode, Moira L. [Arkivoc,2021,vol. 2020,# 3,p. 152 - 170]

5398-44-7 Synthesis