ChemicalBook CAS DataBase List 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid

2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid synthesis

5synthesis methods

Product Name:2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid
CAS Number:35480-52-5
Molecular formula:C11H8F6O4
Molecular Weight:318.17

75-89-8
475 suppliers
$9.00/1g

21739-92-4 Synthesis

21739-92-4
654 suppliers
$8.00/10g

2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid

35480-52-5
277 suppliers
$13.00/1g

Yield:35480-52-5 93.5%

Reaction Conditions:

with C₁₀H₁₂N₂O₈^(4-)*Cu⁽²⁺⁾*2H₄N⁽¹⁺⁾ in N,N-dimethyl-formamide at 20; for 4 h;Reagent/catalyst;

Steps:

1-23; 1-4

S1,After mixing 5mol of EDTA-copper ammonium complex with 5mol of DMF solvent,Put 1mol of 5-bromo-2-chlorobenzoic acid and trifluoroethanol and mix well,React at 20°C for 4h;
S2,The reaction system in step S1 is diluted with 5ml of water,Then adjust the pH to 6 to precipitate crystals;
S3. The crystals precipitated in the step S2 of separation are 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid.

References:

CN112010748,2020,A Location in patent:Paragraph 0026-0043; 0045