ChemicalBook CAS DataBase List 2,4-DICHLORO-5-NITROPYRIDINE

2,4-DICHLORO-5-NITROPYRIDINE synthesis

6synthesis methods

Product Name:2,4-DICHLORO-5-NITROPYRIDINE
CAS Number:4487-56-3
Molecular formula:C5H2Cl2N2O2
Molecular Weight:192.99

7321-93-9 Synthesis

7321-93-9
157 suppliers
$20.00/100mg

4487-56-3
291 suppliers
$24.00/1g

Yield:4487-56-3 77%

Reaction Conditions:

with sulfuric acid;dihydrogen peroxide in water at 0 - 25; for 18 h;

Steps:

1 Synthesis of 2,4-dichloro-5-nitro-pyridine
Fuming H₂SO₄ (13 mL) was added dropwise to the stirred vessel. In a separate flask, concentrated H₂SO₄ was added to 4,6-dichloro-pyridin-3-ylamine (4.54 g, 27.9 mmol) and stirred until complete dissolution occurred. The amine solution was then added to the H₂O₂/fuming H₂SO₄ solution, dropwise. The reaction was allowed to warm to 25° C. over 18 h. The yellow solution was poured over ice and neutralized by the slow addition of solid NaHCO₃. The resultant aqueous solution was extracted three times with EtOAc and the combined organic layers were dried (Na₂SO₄), decanted and concentrated to afford 2,4-dichloro-5-nitro-pyridine as a yellow solid (4.13 g, 77%).